The scientific case for brain simulations.
Gaute T. Einevoll, Alain Destexhe, Markus Diesmann, Sonja Gruen, Viktor Jirsa, Marc de Kamps, Michele Migliore, Torbjorn V. Ness, Hans E. Plesser and Felix Schuermann.

Neuron 102: 735-744, 2019.

Copy of the full paper (PDF)
A key element of the European Union-F¢s Human Brain Project (HBP) and-A other large-scale brain research projects is the simulation of large-scale model networks of neurons. Here, we argue why such simulations will likely be indispensable for bridging the scales between the neuron and system levels in the brain, and why a set of brain simulators based on neuron models at different levels of biological detail should therefore be developed. To allow for systematic refinement of candidate network models by comparison with experiments, the simulations should be multimodal in the sense that they should predict not only action potentials, but also electric, magnetic, and optical signals measured at the population and system levels.