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Reconstructing synaptic background activity from conductance measurements.Quan Zou, Michael Rudolph, Noah Roy, Mavi Sanchez-Vives, Diego Contreras and Alain DestexheNeurocomputing 65: 673-678, 2005. Copy of the full paper (PDF)AbstractTo reconstruct synaptic background activity, we combined computational models with intracellular recordings in vivo. A new conductance analysis method applied to intracellular recordings in the somatosensory cortex of anesthetized rats revealed mirror changes of excitation and inhibition during the up- and down-states of slow waves, but concerted changes in conductance variances. We then used these measurements to constrain the patterns of random release at excitatory and inhibitory synapses in computational models. We show that measurements of the mean and variance of conductances are sufficient constraints to design models fully consistent with in vivo recordings. |